Chromosome instability for tumor progression inference

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Chromosome instability for tumor progression inference

Motivation and Objectives The development and progression of Colorectal Cancer (CRC) as for most other solid cancers, is a multi-step process leading to the accumulation of chromosomal instability (CIN) that occurs over the lifetime of a tumor (Shen et al, 2007; Vogelstein et al, 1988; Fearon et al, 1990). CINs include DNA copy number alterations (CNAs), i.e., regions of aberrantly increased or...

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Autophagy is a bulk degradation process that promotes survival under metabolic stress, but it can also be a means of cell death if executed to completion. Monoallelic loss of the essential autophagy gene beclin1 causes susceptibility to metabolic stress, but also promotes tumorigenesis. This raises the paradox that the loss of a survival pathway enhances tumor growth, where the exact mechanism ...

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Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer

Telomeric dysfunction is linked to colorectal cancer (CRC) initiation. However, the relationship of normal tissue and tumor telomere lengths with CRC progression, molecular features and prognosis is unclear. Here, we measured relative telomere length (RTL) by real-time quantitative PCR in 90 adenomas (aRTL), 419 stage I-IV CRCs (cRTL) and adjacent normal mucosa (nRTL). Age-adjusted RTL was anal...

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I-38: Chromosome Instability in The Cleavage Stage Embryo

Recently, we demonstrated chromosome instability (CIN) in human cleavage stage embryogenesis following in vitro fertilization (IVF). CIN not necessarily undermines normal human development (i.e. when remaining normal diploid blastomeres develop the embryo proper), however it can spark a spectrum of conditions, including loss of conception, genetic disease and genetic variation development. To s...

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High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation

Aneuploidy, an abnormal chromosome number that deviates from a multiple of the haploid, has been recognized as a common feature of cancers for >100 yr. Previously, we showed that the rate of chromosome missegregation/chromosomal instability (CIN) determines the effect of aneuploidy on tumors; whereas low rates of CIN are weakly tumor promoting, higher rates of CIN cause cell death and tumor sup...

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ژورنال

عنوان ژورنال: EMBnet.journal

سال: 2012

ISSN: 2226-6089

DOI: 10.14806/ej.18.b.564